Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1994-05-25
1996-03-05
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530329, 530330, 530331, 562575, 562560, 562444, 562445, C07K 500, C07K 700, C07K 1700, A61K 3800
Patent
active
054969271
ABSTRACT:
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
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Burkhart Joseph P.
Gerhart, deceased Fritz E.
Giroux Eugene L.
Jung Michel J.
Kolb H. Michael
Boudreaux William R.
Huff Sheela J.
Merrell Pharmaceuticals Inc.
Warden Jill
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