Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1995-04-14
1998-01-27
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435163, 435165, 4353201, 4352523, C12P 706, C12N 121, C12N 1574
Patent
active
057121338
ABSTRACT:
The invention relates to microorganisms which normally do not ferment pentose sugar and which are genetically altered to ferment pentose sugar to produce ethanol, and fermentation processes utilizing the same. Examples include Zymomonas mobilis which has been transformed with combinations of E. coli genes for xylose isomerase, xylulokinase, transaldolase, transketolase, L-arabinose isomerase, L-ribulokinase, and L-ribulose 5-phosphate 4-epimerase. Expression of the added genes are under the control of Zymomonas mobilis promoters. These newly created microorganisms are useful for fermenting pentoses and glucose, produced by hydrolysis of hemicellulose and cellulose, to produce ethanol.
REFERENCES:
T. Conway et al., "Glyceraldehyde-3-Phosphate Dehydrogenase Gene from Zymomonas mobilis: Cloning, Sequencing, and Identification of Promoter Region", J. Bacteriol. 169(12):5653-5662, Dec. 1987.
C.Q. Lui et al., "Expression of Cloned Xanthomonas D-Xylose Catabolic Genes in Zymomonas mobilis", J. Biotechnol. 7:61-70, 1988.
M.E. Burnett et al., "Molecular Characterization of the Zymomonas mobilis Enolase Gene", J. Bacteriol. 174(20):6548-6553, Oct. 1992.
S.D. Feldman et al., "Pentose Metabolism in Zymomonas mobilis Wild-Type and Recombinant Strains", Appl. Microbiol. Biotechnol. 38:354-361, 1992.
T. Yura et al. "Systematic Sequencing of the Escherichia coli Genome: Analysis of the 0-2.4 min Region", Nuc. Acids Res. 20(13):3305-3308, Jul. 1992.
G.A. Sprenger, "Aproaches to Broaden the Substrate and Product Range of the Ethanologenic Bacterium Zymomonas mobilis by Genetic Engineering", J. Biotechnol. 27(3) 225-237, Feb. 1993.
Deanda Kristine A.
Eddy Christina K.
Finkelstein Mark
McMillan James D.
Mohagheghi Ali
Eure Ruth
Midwest Research Institute
O'Connor Edna M.
Prouty Rebecca E.
Richardson Ken
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