Penton base protein and methods of using same

Details Penton base protein and methods of using same Penton base protein and methods of using same

1996-09-06

1998-03-24

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

435 697, 4351721, 4351723, 530350, C12N 1586, C12N 1562, C12N 1534, A61K 4800

Patent

active

057311900

ABSTRACT:
A recombinant adenovirus comprising a chimeric penton base protein, which includes a nonpenton base sequence, and a therapeutic gene, a method of gene therapy involving the use of such adenovirus, and adenoviral transfer vectors for the generation of such recombinant adenovirus are provided.

REFERENCES:
patent: 4578079 (1996-03-01), Ruoslahti et al.
patent: 4593002 (1986-06-01), Dulbecco
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 5204445 (1993-04-01), Plow et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5443953 (1995-08-01), Hansen et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5559099 (1996-10-01), Wickham et al.
patent: 5571698 (1996-11-01), Ladner et al.
Karyan et al., Virology, 202, 782-785 (1994).
Database WPI, Week 9017, Derwent Publications Ltd., AN 90-129060/17 (JP 2,078,631 abstract).
Albiges-Rizo et al., "Human adenovirus serotype 3 fiber protein. Comparison of native and recombinant proteins," J. Biol. Chem., 266(6), 3961-3967 (1991).
Bai et al., "Mutations That Alter an Arg-Gly-Asp (RGD) Sequence in the adenovirus Type 2 Penton Base Protein Abolish Its Cell-Rounding Activity and Delay Virus Reproduction in Flatt Cells," Journal of Virology, 67(9), 5198-5205 (1993).
Ball-Goodrich et al., "Parvoviral Target Cell Specificity: Acquisition of fibrotropism by a mutant of the lymphotropic strain of minute Virus involves multiple amino acid substitutions within the capsid," Virology, 184, 175-186 (1991).
Cotten et al., "High-Efficiency Receptor-Mediated Delivery of Small and Large (48 Kilobase) Gene Constructs Using the Endosome-Disruption Activity of Defective or Chemically Inactivated Inactivated Adenovirus Particles," Proc. Natl. Acad. Sci, USA, 89, 6094-6098 (1992).
Curiel et al., "High-Efficiency Gene Transfer Mediated By Adenovirus Coupled to DNA-Polylysine Complexes," Human Gene Therapy, 3, 147-154 (1992).
Greber et al., "Stepwise Dismantling of Adenovirus 2 During Entry Into Cells," Cells, 75, 477-486 (1993).
Hong et al., "The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal," Virology, 185(2), 758-767 (1991).
Horvath et al., "Nonpermissivity of Human Periphral Blood Lymphocytes to Adenovirus Type 2 Infection," Journal of Virology, 62(1), 341-345 (1988).
Komoriya et al., "The Minimal Essential Sequence for a Major Cell Type-Specific Adhesion Site (CSI) Within the Alernatively Spliced Type III Connected Segment Domain of Fiberonectin Is Leucine-Asparitic Acid-Valine," The Journal of Biological Chemistry, 266(23), 15075-15079 (1991).
Mathias et al., "Muliple Adenovirus Serotypes Use .alpha.v Integrins For Infection," Journal of Virology, 68(10), 6811-6814 (1994).
Nemerow et al., "Adenovirus Entry Into Host Cells: A Role For .alpha..sub.v Integrins," Trends In Cell Biology, 4, 52-55 (1994).
Nemerow et al., "The Role of .alpha.v Integrins In Adenovirus Infection," Biology of Vitronectins and Their Receptors, Elsevier Science Pub., Preissner et al., eds., 177-184.
Novelli et al., "Deletion analysis of functional domains in Baculovirus-expressed Adenovirus type 2 fiber," Virology, 185(1), 365-376 (1991).
Silver et al., "Interaction of Human Adenovirus Serotype 2 With Human Lymphoid Cells," Virology, 165, 377-387 (1988).
Stewart et al., "Difference Imaging of Adenovirus: Bridging The Resolution Gap Between X-Ray Crystallography And Electron Microscopy," The EMBO Journal, 12(7), 2589-2599 (1993).
Wickham et al., "Integrins .alpha..sub.v .beta..sub.3 and .alpha..sub.v .beta..sub.5 Promote Adenovirus Internalization But Not Virus Attachment," Cell, 73, 309-319 (1993).
Wickham et al., "Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs," Gene Ther., 2(10), 750-756 (1995).

Affiliated with

Also associated with

Rating

Penton base protein and methods of using same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Penton base protein and methods of using same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Penton base protein and methods of using same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2288099