Pentapeptide with morphine- like activity

Details Pentapeptide with morphine- like activity Pentapeptide with morphine- like activity

1976-12-27

1978-12-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, H61K 3700

Patent

active

041285417

ABSTRACT:
The pentapeptide: H-Tyr-Gly-Gly-Phe-Ser-OH, or a non-toxic salt thereof, exerts an analgesic effect in rats by injection into the lateral brain ventricle.

REFERENCES:
C. Pert, et al.; Science 194, (1976), pp. 330-332.
E. Wei, et al.; Science 193, (1976), pp. 1262-1263.
J. L. DeCoen, et al.; Chem. Abst. 86, (1977), pp. 102130k.
H. Bleich, et al.; Chem. Abst. 86, (1977), pp. 85008g.
Nature; by J. Hughes, et al., 258, (1975), pp. 577-579.
A. Horn, et al.; Nature 260, (1976), pp. 795-797.

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