Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1988-12-21
1993-05-18
Springer, David B.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530331, 530335, 548532, C07C10352
Patent
active
052122875
ABSTRACT:
A method of synthesizing commercial quantities of the pentapeptide L-aspartyl-L-seryl-L-aspartyl-L-prolyl-L-arginine, and salts or solvates thereof, e.g., the hydrochloride or acetate salt or water solvate, compounds useful in pharmaceutical compositions for the treatment of allergic conditions, is disclosed, as are novel intermediate compounds produced in the course of the synthesis.
REFERENCES:
patent: 4161522 (1979-07-01), Hamburger
patent: 4171299 (1979-10-01), Hamburger
S. Guttmann, Helv. Chim. Acta 44, pp. 721-744 (1961).
D. Laufer & E. Blout, JACS 89, pp. 1246-1249 (1967).
Funk Kenneth W.
Gifford Wenying Z.
Tolle John C.
Immunetech Pharmaceuticals, Inc.
Springer David B.
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