Pentapeptide compounds and uses related thereto

Details Pentapeptide compounds and uses related thereto Pentapeptide compounds and uses related thereto

2006-08-29

2006-08-29

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

C514S017400, C514S018700

Reexamination Certificate

active

07098308

ABSTRACT:
Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can serve as a reaction site for joining to a targeting agent, e.g., an antibody, as disclosed.

REFERENCES:
patent: 4414205 (1983-11-01), Pettit
patent: 4816444 (1989-03-01), Pettit et al.
patent: 4879278 (1989-11-01), Pettit et al.
patent: 4978744 (1990-12-01), Pettit et al.
patent: 5410024 (1995-04-01), Pettit et al.
patent: 5521284 (1996-05-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5554725 (1996-09-01), Pettit
patent: 5599902 (1997-02-01), Pettit et al.
patent: 5635483 (1997-06-01), Pettit et al.
patent: 5654399 (1997-08-01), Sakakibara et al.
patent: 5663149 (1997-09-01), Pettit et al.
patent: 5665860 (1997-09-01), Pettit et al.
patent: 5741892 (1998-04-01), Barlozzari et al.
patent: 5767236 (1998-06-01), Kim et al.
patent: 5767237 (1998-06-01), Sakakibara et al.
patent: 5780588 (1998-07-01), Pettit et al.
patent: 5840699 (1998-11-01), Sakakibara et al.
patent: 6004934 (1999-12-01), Sakakibara et al.
patent: 6034065 (2000-03-01), Pettit et al.
patent: 6124431 (2000-09-01), Sakakibara et al.
patent: 6162930 (2000-12-01), Pinney et al.
patent: 6239104 (2001-05-01), Pettit et al.
patent: 6342221 (2002-01-01), Thorpe et al.
patent: 2001/0018422 (2001-08-01), Ritter et al.
patent: 598 129 (1994-05-01), None
patent: 0695757 (1996-02-01), None
patent: 0695758 (1996-02-01), None
patent: 0695759 (1996-02-01), None
patent: WO 93/03054 (1993-02-01), None
patent: WO 95/09864 (1995-04-01), None
patent: WO 96/14856 (1996-05-01), None
patent: WO 96/33212 (1996-10-01), None
patent: WO 01/18032 (2001-03-01), None
patent: WO 04/010957 (2004-02-01), None
Bowman et al. 1950, J. Chem. Soc. 1342-1340.
Miyazaki et al., 1995, “Synthesis and antitumor activity of novel dolastatin 10 analogs,” Chem. Pharm. Bull. (Tokyo) 43(10):1706-1718.
Pettit, 1998, “Antineoplastic agents 365. Dolastatin 10 SAR probes,” Anticancer Drug Des. 13(4):243-277.
Pettit, 1997, “The dolastatins,” (reprint) Springer-Verlag, New York 70:1-79.
Pettit et al., 1996, “The Dolastatins 24. Synthesis of (-)-dolastatin 10. X-ray Molecular Structure of N,N-Dimethylvalyl-valyl-dolaisoleuine, Tert-Butyl Ester”, J. Chem. Soc. Perk Trans. 1:859-863.
Pettit et al., 1995, “Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications,” Anticancer Drug Des. 10(7):529-544.
Pettit et al., 1994, “The Dolastatins. 17. Synthesis of Dolaproine and Related Diastereoisomers,”, J. Org. Chem. 59(21):6287-6295.
Pettit et al., 1996, “The Dolastatins. 18. Stereospecific Synthesis of Dolaproine,”, Synthesis 6:719-725.
Pettit et al., 1994, “The Dolastatins. 19. Synthesis of Dolaisoleuine”, J. Org. Chem. 59(7):1796-1800.
Petit et al., 1996, The Dolastatins. 23: Stereospecific Synthesis of Dolaisoleuine, J. Chem Soc. Perkin. Trans. 1:853-858.
Shioiri et al., 1993, “Stereoselective Synthesis of Dolastatin 10 and its Congeners,” Tetrahedron 49(9):1913-1924.
Tomioka et al., 1991, An Expeditious Synthesis of Dolastatin 10, Tetrahedron Letters 32(21):2395-2398.
Toki et al., 2002, “Cures and Regressions of Established Tumor Xenographs with Monoclonal Antibody”, 223rdACS Meeting, Orlando FL, Apr. 7-11.

Affiliated with

Also associated with

Rating

Pentapeptide compounds and uses related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pentapeptide compounds and uses related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pentapeptide compounds and uses related thereto will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3690826