Pentapeptide antibiotics

Details Pentapeptide antibiotics Pentapeptide antibiotics

1995-05-31

1997-07-15

Scheiner, Toni R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530345, 530322, C07K 500, C07K 700, C07K 1600, C07K 1700

Patent

active

056484569

ABSTRACT:
Pentapeptide antibiotics of the formula ##STR1## wherein W, Z, X.sub.1, X.sub.2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glyccpeptide antibiotics), Y represents a carboxyacid group, a functional derivative of said carboxyacid group or a hydroxymethyl group. The invention includes the salts of the above represented pentapeptide antibiotics with acids or bases as well as their inner salts.
The compounds are obtained by reductive cleavage of the peptidic bond between the second and the third aminoacid of the seven aminoacid chain of dalbaheptides (glycopeptide antibiotics). The inventions concerns also the reductive cleavage process which implies using an alkali metal borohydride as the reagent. The compounds show antibacterial activity against staphylococcal and streptococcal strains.

REFERENCES:
patent: 2990329 (1961-06-01), Philip et al.
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4239751 (1980-12-01), Coronelli et al.
patent: 4322343 (1982-03-01), Debono
patent: 4456593 (1984-06-01), Herrin et al.
patent: 4497802 (1985-02-01), Debono
patent: 4504467 (1985-03-01), Molloy et al.
patent: 4563442 (1986-01-01), Clem et al.
patent: 4639433 (1987-01-01), Hunt et al.
patent: 4643987 (1987-02-01), Nagarajan et al.
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 5438117 (1995-08-01), Malabara et al.
N. Pant et al., J. Am. Chem. Soc. 110, pp. 2002-2003(1988).
R. Nagarajan et al., J. Chem. Soc., Che. Commun., pp. 1306-1307 (1988).
J. Weinstein et al., Annals NY Academy of Sci. vol. 471, pp. 321-323, (1986).
Kirk-Othmer, Encyclopedia of Chemical Technology, 3rd Edition, vol. 2, A Wiley Interscience Publication, pp. 809, (1978).
Gennaro, A.R., Remington's Pharmaceutical Sciences 18th ed., Pharmaceuticals Sciences, (1990), p. 757, 1163, 1214-1215.
Gilman, A.G., Rail, T.W., Nies, A.S., Taylor, P., Ed., Goodman and Gilman's The Pharmacological Basis of Therapeutics 8th ed., Pergamon Press, (1990), pp. 1018-1034.
Demain, A.L., Solomon, N.A., Ed., Manual of Industrial Microbiology and Biotechnology, American Soc. for Microbiology, (1986), pp. 24-26.
Budavari, S., O'Neil, M.J., Smith, A., Heckelman, P.E., Ed., The Merck Index, 11th ed., (1989), p. 1438, 1311, 1561.
Malabarba et al., J. Antibiotics vol. 37 No. 9 pp. 988-999, (1984).

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