Pentafluorobenzenesulfonamides and analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S403000, C514S415000, C546S307000, C546S312000, C548S362100, C548S503000, C548S509000

Reexamination Certificate

active

07138418

ABSTRACT:
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:

REFERENCES:
patent: 1955207 (1934-04-01), Stotter et al.
patent: 2402623 (1946-06-01), Hester
patent: 3034955 (1962-05-01), Frick et al.
patent: 4443477 (1984-04-01), Witte et al.
patent: 4881969 (1989-11-01), Saupe et al.
patent: 4883914 (1989-11-01), Alvarado et al.
patent: 4900867 (1990-02-01), Wilkes et al.
patent: 5093340 (1992-03-01), Mohrs et al.
patent: 5250549 (1993-10-01), Yoshino et al.
patent: 5385931 (1995-01-01), Bigg et al.
patent: 5387709 (1995-02-01), Lardy et al.
patent: 5591503 (1997-01-01), Pews et al.
patent: 5610320 (1997-03-01), Yoshino et al.
patent: 5773236 (1998-06-01), Diwu et al.
patent: 5880151 (1999-03-01), Medina et al.
patent: 5891917 (1999-04-01), Tang et al.
patent: 6121304 (2000-09-01), Flygare et al.
patent: 6153585 (2000-11-01), Rubenstein et al.
patent: 6284923 (2001-09-01), Medina et al.
patent: 6316484 (2001-11-01), Flygare et al.
patent: 6355628 (2002-03-01), Schwendner et al.
patent: 6388131 (2002-05-01), Medina et al.
patent: 6417176 (2002-07-01), Houze
patent: 6482860 (2002-11-01), Flygare et al.
patent: 6630513 (2003-10-01), Rubenstein et al.
patent: 2002/0177548 (2002-11-01), Schwendner et al.
patent: 2003/0162817 (2003-08-01), Flygare et al.
patent: 3623184 (1992-02-01), None
patent: 0391799 (1990-10-01), None
patent: 0 472 449 (1992-02-01), None
patent: 469901 (1992-02-01), None
patent: 0469901 (1992-02-01), None
patent: 0472499 (1992-02-01), None
patent: 1242057 (1971-08-01), None
patent: 1306564 (1973-02-01), None
patent: WO 97/30677 (1997-08-01), None
patent: WO 99/24407 (1999-05-01), None
Posner et al., CAPLUS Abstract 107:23211, 1987.
Iwata et al., CAPLUS Abstract 116:214490, 1992.
Nazareth et al., CAPLUS Abstract 102:109290, 1985.
Ishii et al., CAPLUS Abstract 108:177077, 1988.
Vega et al., PubMed Abstract (Circulation, 84(1):118-28) Jul. 1991.
Hawkinson et al., “Studies of solvolysis . . . ”,Journal of Organic Chemistry, 53:(16) 3857-3860, 1988.
Shealy et al., “2- Haloethylating Agents for Cancer Chemotherapy, 2-Haloethyl Sulfonaes”,Journal of Medicinal Chemistry, p. 1168-1173, (Aug. 6, 1983).
Olander et al., “A Study of the Binding of Two Sulfonamides to Carbonic Anhydrase”,Journal of American Chemical Socety, 95:(5) 1616-1621 (Mar. 7, 1973).
Fielding et al., “Synthesis and Reactions of 4-sulpho-2,3,5,6-tetrafluorobenzoic Acid.”,Journal of Florine Chemistry, 59(1) 15-31 (Jan. 6, 1992).
Raibekas et al. “Affinity Probing of Flavin Binding Sites.2. Identification of reactive Cysteine in the Flavin domain ofEscherichia coliDNA Photolyase”,Biochemistry, 33(42) 12656-12664 (Jan. 6, 1994).
Yoshimoto et al., “Correclation Analysis of Baker's Studies . . . ”,J. Med. Chem, 19:(1)) 71-98 (1976).
Bai et al., “Identification of the cysteine residue of β-Tubulin alkylated by the antimitotic agent 2,4-Dichlorobenzyl Thiocyanate, facilitated by separation of the protein subunits of Tibulin by hydrophobic column chromatography” Biochemistry 28:5606-5612 (1989).
Fadeeva et al., “Gas-chromatographic separation of sulfur and fluorin-containing pyrolysis products” Chemical Abstracts 76:5 (1972).
Luduena et al., “Interaction of ethacrynic acid with bovine brain tubulin” Biochemical Pharmacology 47(9):1677-1681 (1994).
March,Advanced Organic Chemistry4th Ed. p. 497 (1992).
U.S. Appl. No. 08/605,431, filed Feb. 22, 1996, Flygare et al.
Gerig, J. and Moses, J., “Aromatic ring dynamics in a carbonic anhydrase-inhibitor complex” J. Chem. Soc., Chem. Commun. 6:482-484 (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pentafluorobenzenesulfonamides and analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pentafluorobenzenesulfonamides and analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pentafluorobenzenesulfonamides and analogs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3640151

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.