Pentafluorobenzenesulfonamides and analogs

Details Pentafluorobenzenesulfonamides and analogs Pentafluorobenzenesulfonamides and analogs

1997-07-18

1999-03-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

5142388, 514602, 514604, 558 56, 558 61, 564 90, 564 92, 544166, A61K 31535, A01N 4102, C07C30300, C07D26530

Patent

active

058801510

ABSTRACT:
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##

REFERENCES:
patent: 1955207 (1934-04-01), Stotter et al.
patent: 2402623 (1946-06-01), Hester
patent: 3034955 (1962-05-01), Frick et al.
patent: 4881969 (1989-11-01), Saupe et al.
patent: 4883914 (1989-11-01), Alvarado et al.
patent: 5250549 (1993-10-01), Yoshino et al.
Fielding et al. Synthesis and Reactions of 4-sulpho-2,3,5,6-tetrafluorobenzoic Acid, Journal of Fluorine Chemistry. 1992, vol. 59, No. 1, pp. 15-31.
Raibekas et al. Affinity Probing of Flavin Binding Sites. 2. Identification of Reactive Cysteine in the Flavin Domain of Escherichia coli DNA Photolyase. Biochemistry. 1994, vol. 33, No. 42, pp. 12656-12664.
Shealy et al., 2-Haloethylating Agents for Cancer Chemotherapy. 2-Hloethyl Sulfonates. Journal of Medicinal Chemistry. Aug. 1983, vol. 26, pp. 1168-1173.
Olander et al. A Study of the binding of twoo sulfonamides to Carbonic Anhydrase. Journal of American Chemical society. 07 Mar. 1973, vol. 95, No. 5, pp. 1616-1621.
Hawkbon et. al., "Studies of Solvolysis . . . ", J. Org. Chem., 1988, vol. 53(16), pp. 3857-3860.

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