Pentacyclic phenylpyrazole compounds as anti-inflammatory agents

Details Pentacyclic phenylpyrazole compounds as anti-inflammatory agents Pentacyclic phenylpyrazole compounds as anti-inflammatory agents

1982-01-13

1983-11-01

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544231, 548371, 568328, A10K 31505, C07D23154, C07D49120

Patent

active

044129955

ABSTRACT:
Compounds of the formula ##STR1## where R is hydrogen, methyl, ethyl, propyl, 2-propenyl or 2-propynyl; and R' is hydrogen or fluoro possess anti-inflammatory activity. The compounds where R is H are prepared by reacting a compound of the formula ##STR2## with (1H,3H)-pyrimidine-2,4,5,6-tetrone. The compounds where R is other than hydrogen are prepared by reacting a compound where R is hydrogen with the appropriate alkylating agent.

REFERENCES:
Fried et al., J. Am. Chem. Soc. 85, 236-238 (1963).

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