Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1996-11-15
1998-05-26
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
514 2, A61K 3800, C07K 200, C07K 400, C07K 500
Patent
active
057566615
ABSTRACT:
The invention comprises a leucine aminopeptidase inhibitor (LAPI) having hemagglutination activity which is extracted from the seeds of Pentaclethra macroloba. The crude extract was found to comprise an active species having a molecular weight in the range 1.5-60 kilodaltons and further comprises an amino acid containing component, a fluorescent component and sugars. The basic unit of the active species contains approximately the following type and number of amino acid residues averaged over a plurality of separations and analyses: 3 aspartate, 3 threonine, 4.5 serine, 3.75 glutamic, 6.5 glycine, 3.5 alanine, 2.25 valine, 1.25 isoleucine, 2 leucine, 0.75 tyrosine, 1.25 phenylalanine, 5.25 lysine, 0.75 histidine, 2.25 arginine and 0.625 proline, and forms multimers, adduct, conjugate and similar species between by itself or with proteinaceous, fluorescent and sugar substance which may also be present. The active substance(s) act as an insecticide and have been found to increase insect mortality in bioassays. The active substance(s) are particularly effective against European corn borer larvae.
REFERENCES:
Insecticidal Action of the Phytohemagglutinin in Black Beans on a Bruchid Beetle; Janzen, Daniel H., Science, vol. 1192, May 21, 1976, pp. 795-796.
Pentaclethra macroloba Seed effect on Larval Growth, Cell Viability, and Midgut Enzyme Activity of Helicoverpa zea (Lepidoptera: Noctuidae); J. of
Toxicity of Secondary Compounds to the Seed-eating Larvae of the Bruchid Beetle--Callosobruchus Maculatus--Phytochemistry, 1977, vol. 16, pp. 223-227.
Potentially Defensive Proteins in Mature Seeds of 59 Species of Tropical Leguminosae--Journal of Chemical Ecology, vol. 12, No. 6, 1986.
Czapla Thomas H.
Rathburn Harold B.
Reimann-Philipp Ulrich
Schubert Karel R.
Harle Jennifer
Pioneer Hi-Bred International , Inc.
Tsang Cecilia J.
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