Penta and tetrasubstituted piperidines and compositions and meth

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514315, 546236, 546248, A61K 31445, C07D21122

Patent

active

052907899

ABSTRACT:
The invention is related to compounds, being useful in treating psychosis, of the formula: ##STR1## wherein: R.sup.1 is hydrogen, lower-alkyl or phenyl-lower-alkyl;

REFERENCES:
patent: 3097212 (1963-07-01), Jucker
patent: 3422451 (1969-01-01), Cope
patent: 3431267 (1969-03-01), Welcher
patent: 5023266 (1991-06-01), Langer et al.
Schneider et al "Preparation of 3(4-Hydroxyl Alkyl) Substituted N-piperidines", CA 68: 21794f (1968).
Yanina et al "Hofmann Degradation of 1-Azabycyclo[3,2,1] Octane" CA 58: 13909g (1963).
Cervinka "Enamines. V." CA 55: 4507c (1961).
Loew, et al., Endog. Exog. Opiate Agonists and Antagonists, E. L. Way, editor, Pergamon: Elmsford, New York 1980, pp. 39-42.
Glennon, et al., J. Med. Chem. 1991, 34, 3360-3365.

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