Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-05-29
1999-10-26
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 435 6, C07H 2102, C07H 2104, C12Q 168
Patent
active
059731311
ABSTRACT:
Disclosed is a Penicillium marneffei PMAP1 polypeptide and DNA(RNA) encoding such PMAP1 polypeptide. Also provided is a procedure for producing such polypeptide by recombinant DNA techniques and a procedure for generating antibodies against the said polypeptide. Also disclosed is a method of using such polypeptide and the antibodies against it for the diagnosis of systemic infections of Penicillium marneffei by detecting the presence of the specific antibodies as well as the PMAP1 protein antigen in clinical specimens taken from suspected patients. Also provided are methods of using the PMAP1 DNA(RNA) or protein sequence to identify and to clone its homologous genes from other pathogenic fungi. Therefore, the identification of PMAP1 homologous genes from other pathogenic fungi are made possible with this invention. Also described is a therapeutic regimen using the antibodies against Penicillium infection. Also provided is a method of immunization against the infection of Penicillium.
REFERENCES:
The Promega Catalog (1993/1994 Edition) p. 189.
Sommer et al., Nucleic Acids Research 17(16) : 6749 (1989).
The Promega Catalog (1993/1994 Edition) p. 92.
Chongtrakool et al., J. of Clinical Microbiology 35(9) : 2220-2223 (1997).
LoBuglio et al., J. of Clinical Microbiology 33(1) : 85-89 (1995).
Vanittanakom et al., J. of Clinical Microbiology 34(7) : 1834-1836 (1996).
Sundstrom and Aliaga (1992) Molecular Cloning c DNA and Analysis of Protein Secondary Structure of Candida albicans Enolase, an Abundant, Immunodominant Glycolytic Enzyme Journal of Bacteriology 174: 6789-6799. (Exhibit A).
Supparatpinyo et al. (1994) Disseminated Pencillium marneffei Infection in Southeast Asia. The Lancet 344: 110-113. (Exhibit B).
Yuen et al. (1994) Serodiagnosis of Penicillium marneffei Infection. The Lancet 344:444-446 (Exhibit C).
Walsh et al. (1991) Detection of Circulating Candida Enolase by Immunoassay in Patients with Cancer and Invasive Candidiasis. The New England Journal of Medicine 324: 1026-1031. (Exhibit D).
Cao Liang
Yuen Kwok Yung
Jones W. Gary
Katz Robert D.
Whisenant Ethan
LandOfFree
Penicillium marneffei antigenic Protein 1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Penicillium marneffei antigenic Protein 1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Penicillium marneffei antigenic Protein 1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-766192