Penicillins substituted with heterocyclic groups

Details Penicillins substituted with heterocyclic groups Penicillins substituted with heterocyclic groups

1974-07-25

1976-04-20

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49944

Patent

active

039519554

ABSTRACT:
A penicillin of the formula: ##SPC1##
Wherein A is a substituted or unsubstituted condensed aromatic carbocyclic or heterocyclic ring, R is hydrogen or lower alkyl, X is oxygen or sulfur, Y is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl and Z is phenyl or thienyl which can be produced by reacting 6-aminopenicillanic acid or its ester with a carboxylic acid of the formula: ##SPC2##
Wherein A, R, X, Y and Z are each as defined above or its reactive derivative. The said penicillin and its non-toxic salts have a broad antimicrobial spectrum against various gram-positive and gram-negative bacteria, and they exhibit characteristically a strong antimicrobial activity against Pseudomonas.

REFERENCES:
patent: 3770722 (1973-11-01), Bright et al.

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