Drug – bio-affecting and body treating compositions – Plural fermentates of different origin
Patent
1983-08-01
1985-12-31
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Plural fermentates of different origin
2602452R, 514192, C07D49900, A61K 31425
Patent
active
045620733
ABSTRACT:
A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 is hydrogen or trialkylsilyl; R.sub.2 is hydrogen, trialkylsilyl or COOR.sub.2 ' wherein R.sub.2 ' is hydrogen, C.sub.1-18 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl or group for forming a pharmaceutically acceptable salt; and R.sub.3 has the same meaning as above R.sub.2 '.
REFERENCES:
patent: 4331677 (1982-05-01), Foglio et al.
Ishida Naobumi
Kajitani Makoto
Micetich Ronald G.
Tanaka Motoaki
Yamabe Shigeru
Rizzo Nicholas S.
Taiho Pharmaceutical Company Limited
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