Penicillin derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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2602391, 424271, A61K 3167, A61K 3143, C07D49946, C07F 965

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active

043082599

ABSTRACT:
A penicillin of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R is C.sub.1-6 alkyl; an optionally substituted 5-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, sulphur and nitrogen; phenyl; mono-substituted phenyl where the substituent is halogen, hydroxy, C.sub.1-6 alkoxy, nitro, amino, C.sub.1-6 alkyl, or C.sub.1-6 haloalkyl, C.sub.1-6 alkylcarbonyloxy, or C.sub.1-6 alkyl sulphonylamino; or di-substituted phenyl where the substituents are selected from hydroxy, halogen, methoxy, acetoxy and amino; and X represents a group of formula: ##STR2## wherein R.sup.1 represents C.sub.1 to C.sub.6 alkyl, or C.sub.1 to C.sub.6 alkoxy.
Their preparation and use is described.

REFERENCES:
patent: 3966710 (1976-06-01), McFarland et al.
patent: 4048158 (1977-09-01), Sugimoto et al.
patent: 4057544 (1977-11-01), Sugimoto et al.
patent: 4060530 (1977-11-01), Howarth et al.
patent: 4185014 (1980-01-01), Taylor et al.
patent: 4197240 (1980-04-01), Nudelman et al.

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