Drug – bio-affecting and body treating compositions – Plural fermentates of different origin
Patent
1984-10-05
1987-05-26
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Plural fermentates of different origin
540310, 540304, 514192, 514195, C07D49900, A61K 31425
Patent
active
046685146
ABSTRACT:
This invention provides a penicillin derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, C.sub.3-9 acyloxyalkyl, C.sub.8-13 benzyloxyalkyl, C.sub.2-7 alkoxyalkyl, C.sub.2-7 alkoxycarbonyl, C.sub.3-8 alkenyloxycarbonyl, C.sub.3-8 alkynyloxycarbonyl, phenyl, amino, cyano, formyl, trifluoromethyl, C.sub.2-6 acyl, carbamoyl, C.sub.2-7 alkylcarbamoyl, benzyloxycarbonylamino, C.sub.2-7 alkoxycarbonylamino; and R.sub.3 is hydrogen, a group for forming a pharmaceutically acceptable salt, or a penicillin carboxyl protecting group, with the proviso that both of R.sub.1 and R.sub.2 are not hydrogen or C.sub.2-7 alkoxycarbonyl at the same time and that when one of R.sub.1 and R.sub.2 is hydrogen, the other is not C.sub.2-7 alkoxycarbonyl, or a pharmaceutically acceptable acid addition salt, process for preparing the derivative, and a pharmaceutical composition containing the derivative.
REFERENCES:
patent: 4507239 (1985-03-01), Micetich et al.
patent: 4562073 (1985-12-01), Micetich et al.
Ishida Naobumi
Kajitani Makoto
Micetich Ronald G.
Tanaka Motoaki
Yamabe Shigeru
Rizzo Nicholas S.
Taiho Pharmaceutical Company Limited
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