Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-04-22
1985-01-29
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424270, 260239A, 2602452T, C07D49900, A61K 31425
Patent
active
044964846
ABSTRACT:
This invention provides a penicillin derivative of the formula and a salt thereof ##STR1## wherein X represents chlorine atom or bromine atom and R represents hydrogen atom or penicillin carboxy-protecting radical, and a process for preparing the derivative of the formula (I) and a salt thereof by reacting a compound of the formula ##STR2## wherein R is as defined above with a chlorinating reagent or brominating reagent and, when required, forming a salt thereof.
REFERENCES:
patent: 4009159 (1977-02-01), Kamiya et al.
patent: 4036847 (1977-07-01), Kamiya et al.
patent: 4071527 (1978-01-01), Kamiya et al.
patent: 4234579 (1980-11-01), Barth
patent: 4340539 (1982-07-01), Gottstein
Gottstein et al., J. Med. Chem., 1981, vol. 24, 1531-1534.
Hirata Shoji
Ishida Naobumi
Micetich Ronald G.
Yamabe Shigeru
Ferguson Jr. Gerald J.
Murray Robert B.
Rizzo Nicholas S.
Taiho Pharmaceutical Company Limited
Whisenhunt Fred S.
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