Penicillin conversion by halogen electrophiles and anti-bacteria

Details Penicillin conversion by halogen electrophiles and anti-bacteria Penicillin conversion by halogen electrophiles and anti-bacteria

1977-02-25

1982-06-22

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602454, C07D20508

Patent

active

043361919

ABSTRACT:
Novel beta-lactam compounds of the formula ##STR1## and process for their preparation in which a penicillin ester is reacted with a source of positive halogen to selectively open the thiazolidine nucleus of the penicillin. These compounds are useful as intermediates in the preparation of novel anti-bacterial compounds of the formula: ##STR2##

REFERENCES:
patent: 3064042 (1962-11-01), Sernivk
patent: 3644458 (1972-02-01), Kampe
patent: 3803224 (1974-04-01), Phillips
J. M. Steward et al., J. Amer. Chem. Soc. 24, 5880 (1952).
S. Kukolja, J. Amer. Chem. Soc, 93, 6268.
Barton et al., Chem. Comm. 1971, 1137-1139.
Douglass et al., J. Org. Chem. 15, 795 (1950).
Bailar et al., "Comprehensive Chemistry", vol. 2, pp. 858, 1344-1347.
Kharasch et al., "Organic Synthesis", vol. 44, pp. 47-50.
B. Taub, J. Org. Chem. 25, 263-264 (1960).

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