Penetration enhancers for transdermal delivery of systemic agent

Details Penetration enhancers for transdermal delivery of systemic agent Penetration enhancers for transdermal delivery of systemic agent

1988-08-17

1989-12-12

Friedman, Stanley

Textiles: spinning, twisting, and twining

514 50, 514179, 514183, 514212, 514269, 514315, 514316, 514327, 514328, 514330, 514919, 514948, 514947, A61V 3170

Patent

active

048867837

ABSTRACT:
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-16 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen.

REFERENCES:
Barry et al., Proc. Royal Irish Academy, "Antitubercular Substances", vol. 55, pp. 137-148 (1953).
Chem. Abst. 106:67103m (1986).
Chem. Abst. 106:84339k (1986).
Chem. Abst. 102:183860x (1985).
Chem. Abst. 69:86313p (1968).

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