Penetration enhancers for transdermal delivery of systemic agent

Details Penetration enhancers for transdermal delivery of systemic agent Penetration enhancers for transdermal delivery of systemic agent

1992-11-06

1993-12-14

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Penetrant or absorbent

424 47, 514 29, 514317, 514944, 514969, A61K 906, A61K 912, A61K 3170, A61K 31445

Patent

active

052703460

ABSTRACT:
This invention relates to a method for administering systemically active agents, including therapeutic agents, through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent a non-toxic, effective, penetrating amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X represents sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen.

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