Penetration enhancers for transdermal delivery of systemic agent

Details Penetration enhancers for transdermal delivery of systemic agent Penetration enhancers for transdermal delivery of systemic agent

1990-08-06

1993-04-20

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514327, 514356, 514392, 514420, 514470, 514567, 514650, 514653, 514742, 514946, 514947, A61K 3156, A61K 31445, A61K 3144, A61K 31415, A61K 3140, A61K 3134, A61K 31195, A61K 31135, A61K 3104

Patent

active

052043398

ABSTRACT:
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X is selected from the group consisting of oxygen and sulfur; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-17 and R is --CH.sub.3 ; wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.

REFERENCES:
patent: 3051616 (1962-08-01), Drapal
patent: 3085931 (1963-04-01), Darlington
patent: 3157641 (1964-02-01), Walles et al.
patent: 3306910 (1967-02-01), Louthan
patent: 3306911 (1967-02-01), Doss
patent: 3332938 (1967-07-01), Mayhew et al.
patent: 3342673 (1967-09-01), Kaufman et al.
patent: 3551544 (1970-12-01), Herschler
patent: 3598122 (1971-08-01), Zaffaroni
patent: 3598123 (1971-08-01), Zaffaroni
patent: 3678156 (1972-07-01), MacMillan et al.
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3742951 (1973-06-01), Zaffaroni
patent: 3814097 (1974-06-01), Ganderton et al.
patent: 3823152 (1974-07-01), Morimoto et al.
patent: 3865814 (1975-02-01), Lussi et al.
patent: 3891757 (1975-06-01), Higuchi
patent: 3921636 (1975-11-01), Zaffaroni
patent: 3954966 (1976-05-01), Lim et al.
patent: 3960922 (1976-06-01), Baker et al.
patent: 3966806 (1976-06-01), Baker et al.
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 3989815 (1976-11-01), Rajadhyaksha
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 3991203 (1976-11-01), Zaffaroni
patent: 3993072 (1976-11-01), Zaffaroni
patent: 3993073 (1976-11-01), Zaffaroni
patent: 3996934 (1976-12-01), Rajadkyaksha
patent: 4021224 (1977-05-01), Pallos et al.
patent: 4031894 (1977-06-01), Urfahart
patent: 4060084 (1977-11-01), Chandrasekoran et al.
patent: 4069307 (1978-01-01), Higuchi et al.
patent: 4077407 (1978-03-01), Theeumes
patent: 4118500 (1978-10-01), Pritzlaff et al.
patent: 4122170 (1978-10-01), Rajadhyaksha
patent: 4201211 (1980-05-01), Chandrasekoran et al.
patent: 4230105 (1980-10-01), Harwood
patent: 4264594 (1981-04-01), McGovern et al.
patent: 4284648 (1981-08-01), Hussain et al.
patent: 4292299 (1981-09-01), Suzuki
patent: 4292303 (1981-09-01), Keith et al.
patent: 4310525 (1982-01-01), Nelson
patent: 4311481 (1982-01-01), Nelson
patent: 4316893 (1982-02-01), Rajadhyaksha
patent: 4364952 (1982-12-01), Materne
patent: 4405616 (1983-09-01), Rajadhyaksha
patent: 4415563 (1983-11-01), Rajadhyaksha
patent: 4423044 (1983-02-01), Rajadhyaksha
patent: 4424210 (1984-01-01), Rajadhyaksha
patent: 4440777 (1984-04-01), Zupan
patent: 4444762 (1984-04-01), Rajadhyaksha
patent: 4525199 (1985-06-01), Rajadhyaksha
patent: 4537776 (1985-08-01), Cooper
patent: 4552872 (1985-11-01), Cooper
patent: 4557934 (1985-12-01), Cooper
patent: 4562075 (1985-12-01), Rajadhyaksha
patent: 4565823 (1986-01-01), Ohata et al.
patent: 4605670 (1986-08-01), Saito
patent: 4620949 (1986-11-01), Ohata et al.
patent: 4621143 (1986-11-01), McGovern et al.
patent: 4626539 (1986-12-01), McGovern et al.
patent: 4654209 (1987-03-01), Leslie et al.
patent: 4743588 (1988-05-01), Mirejovsky et al.
Remington's Pharmaceutical Sciences, 16th ed. (1980) p. 431.
Chemical Abstracts 69:86313p (1960).
Chemical Abstracts 99:181394u (1980).
Chemical Abstracts 106:67103m (1987).
Chemical Abstracts 106:84339k (1987).
The Merck Index, 9th ed., abstracts #4450 & 6429 (1980).
Chem. Abst. 83:1758d (1974).
Chem. Abst. 82:39533u (1974).
Chem. Abst. 82:93905e (1974).
Chem. Abst. 83:91780g (1975).
Chem. Abst. 104:213242h (1985).

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