Penetration enhancers for transdermal delivery of systemic agent

Details Penetration enhancers for transdermal delivery of systemic agent Penetration enhancers for transdermal delivery of systemic agent

1986-10-07

1989-01-31

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514316, 514326, 514441, 514448, 514919, 514947, 514946, 540525, 540529, 540530, 546290, 546281, 546265, 546262, 546194, 546193, 548524, 548546, 548548, 548521, 8564, 71 88, 71 94, 71 95, 502167, A61K 3133, A61K 3130, A01N 2502

Patent

active

048015865

ABSTRACT:
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X and Y, each, may represent sulfur, oxygen or two hydrogen atoms, A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having 1-4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkylformyl; m is 3-7; q is 2m-2x, wherein x equals the number of double bonds in the lactam ring and may be 1, 2 or 3, and R is CH.sub.3, ##STR2## wherein R" is H or halogen.

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Rothe and Toth, Chem. Ber. Band 99, No. 12, pp. 3820-3829 (1966).
English Abstract of Spanish patent application E.S. No. 549,688 (1986) to Jesus Tremme Lozano.

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