Penetration enhancer for transdermal delivery of systemic agents

Details Penetration enhancer for transdermal delivery of systemic agents Penetration enhancer for transdermal delivery of systemic agents

1990-01-22

1992-06-02

Page, Thurman K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

424448, 424449, C07C23300

Patent

active

051188457

ABSTRACT:
This invention relates to a method administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 20 carbon atoms and R is selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 30 carbon atoms; provided, however, that the total number of carbon atoms in said compound is 15 or more and the total number of carbon atoms in R.sup.1 and R.sup.2 is 5 or more.

REFERENCES:
patent: 4506056 (1985-03-01), Gaylord

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