Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1983-06-21
1985-12-10
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
424 88, 514399, 514947, 514635, 514374, 514159, 514165, 514231, 514270, A01N 5926, A61K 3342
Patent
active
045579342
ABSTRACT:
Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C.sub.3 -C.sub.4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.
REFERENCES:
patent: 1974 (1879-01-01), Wickett et al.
patent: 296706 (1881-08-01), Cooper
patent: 383391 (1882-06-01), Cooper
patent: 506273 (1883-05-01), Cooper
patent: 506274 (1883-05-01), Cooper et al.
patent: 2990331 (1961-06-01), Neumann et al.
patent: 3535422 (1970-10-01), Cox et al.
patent: 3934013 (1976-01-01), Poulsen
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 4006218 (1977-02-01), Sipos
patent: 4017641 (1977-04-01), DiGiulio
patent: 4070462 (1978-02-01), Ecker
patent: 4075353 (1978-02-01), Mandy
patent: 4126681 (1978-11-01), Reller
patent: 4132781 (1979-01-01), Stoughton
patent: 4289764 (1981-09-01), Yarrow
patent: 4299826 (1981-11-01), Luedders
patent: 4316893 (1982-02-01), Rajadhyaksha
patent: 4343798 (1982-08-01), Fawzi
patent: 4424210 (1984-01-01), Rajadhyaksha
Stoughton, "Enhanced Percutaneous Penetration with 1-Dodecylazacycloheptan-2-one", Arch. Derm., 118, pp. 474-477, (1982).
Rosuold, J. et al., "Effect of Formulation on In Vitro Release and In Vivo Absorption of Corticosteroids from Ointments", Medd. Novsk Favm Selsk, 44, 21-45, (1982).
Anjo, D. M. et al., "Methods for Predicting Percutaneous Penetration in Man", Percutaneous Absorption of Steroids, pp. 31-51, Academic Press NY, NY, (1980).
CA 92:153,181j.
H. Barnes, et al., Br. J. Derm. 93, 459, (1975).
P. J. W. Ayres, et al., Br. J. Derm., 99, 307, (1978).
Schaaf and Gross, Dermatologica, 106, 357, (1953).
J. Zatz, et al., J. Pharm. Sci., 67, 789, (1978).
S. K. Chandrasekaran, et al., J. Pharm. Sci., 67, 1370, (1978).
B. Idson, Cosmetics & Toiletries, 95, 59, (1980).
M. M. Rieger, Cosmetics & Toiletries, 94, 32-37, (1979), and 95, 26-38, (1980).
CA 79: 122,308.
Allen George W.
Goldstein Steven J.
Roberts Elbert L.
Schaeffer Jack D.
The Procter & Gamble & Company
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