Penetrating topical pharmaceutical compositions

Details Penetrating topical pharmaceutical compositions Penetrating topical pharmaceutical compositions

1989-02-15

1990-09-04

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514420, 514569, 514570, 514947, A61K 3160

Patent

active

049544870

ABSTRACT:
A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C.sub.3 -C.sub.4 diol, diol ester, or diol ether and (2) a cell envelope-disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.

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