Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1981-06-08
1982-10-12
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424230, 424235, 424240, 424331, A61K 1156, A61K 3160, A61K 31605, A61K 3578
Patent
active
043538967
ABSTRACT:
An improved topical medicament useful in treating athletic injuries or other painful subdermal conditions is provided which includes a penetrating solvent such as dimethylsulfoxide (DMSO) along with, in preferred forms, a corticosteroid (e.g., hydrocortisone acetate), a counterirritant/analgesic such as methyl salicylate, and one or more emulsifiers, a rubifacient and an alcoholic carrier. The medicaments hereof, when applied topically, are absorbed through the skin and serve to transport the corticosteroid and/or analgesic to a site of inflammation. The preferred salicylate component is converted to the analgesic salicyic acid and active metabolites in the bloodstream to serve as a pain killing agent (i.e., a prostaglandin inhibitor). The compositions hereof may be in the form of lotions, creams or aerosols, depending upon desired end use.
REFERENCES:
patent: 2801202 (1957-07-01), Poetsch
patent: 2815315 (1957-12-01), Pottier
patent: 2880130 (1959-03-01), Johnson
patent: 2880138 (1959-03-01), Johnson
patent: 2890152 (1959-06-01), Babcock, Jr. et al.
patent: 3019162 (1962-01-01), Brunner et al.
patent: 3053737 (1962-09-01), Johnson
patent: 3474168 (1969-10-01), Schayer
patent: 4012508 (1977-03-01), Burton
Merck Index, 9th Ed., (1976), p. 433.
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