Penetrating antibiotic gel for soft tissue diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S027000, C514S028000, C514S030000, C514S031000, C514S450000, C514S763000, C514S769000, C514S772000, C514S772300, C514S774000, C514S777000, C514S778000, C514S781000, C514S782000, C514S825000, C514S886000, C514S887000, C514S937000, C514S944000, C514S946000, C424S400000, C424S450000, C424S484000, C424S486000, C424S488000

Reexamination Certificate

active

06914051

ABSTRACT:
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an antibiotic compound and a mobilizing agent in an amount sufficient to enable the antimicrobial compound to penetrate into the sub-dermal soft tissues. The antimicrobial compound may be a macrolide antibiotic compound such as azithromycin, erythromycin or roxithromycin, for example, and the mobilizing agent may be an organogel compound, such as pluronic lecithin liposomal organogel (PLO). The composition may further include a penetration enhancing adjuvant, such as d-limonene, for example. The composition may be applied topically so as to penetrate into the sub-dermal soft tissues, or may injected so as to be absorbed into the soft tissues locally.

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patent: 95/09601 (1995-04-01), None
Chemical Abstracts 132:69251 (1999).
Oh, Yu-Kyoung et al., “Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection,” Antimicrobial Agents and Chemotherapy, vol. 39, No. 9, Sep. 1995, pp. 2104-2111.
Chemical Abstracts 85:87225 (1976).
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Chemical Abstracts 100:73895 (1984).
Backman et al. (Abstract only) Zeitschrift fur Rheumatologie—Nov.-Dec. 1983.

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