Pencillins having a 6.beta.-(.alpha.-etherified oximino) acylami

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424271, C07D49970

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active

039753760

ABSTRACT:
The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids, and nontoxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds may be either syn or anti isomers or may exist as mixtures e.g. containing at least 75% of one isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive organisms including penicillinase - producing staphylococci coupled with high activity against strains of the gram-negative organism Haemophilus influenzae. The invention is also concerned with the administration of the compounds.

REFERENCES:
moses et al., Arkiv For Kemi, 22 (33), 451- 467, (1964).
Ekstrom et al., Acta Chemica Scandinavica 19, 281-299, (1965).

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