Penam 1,1-dioxides as beta-lactamase inhibitors

Details Penam 1,1-dioxides as beta-lactamase inhibitors Penam 1,1-dioxides as beta-lactamase inhibitors

1978-09-01

1980-12-23

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

2602452R, C07D27760, A61K 31425, A61K 3143

Patent

active

042410509

ABSTRACT:
(3S, 5R)-Penam-3-carboxylic acid 1,1-dioxide, optionally having a methyl group at the 2-position, and esters thereof readily hydrolyzable in vivo, are useful for enhancing the effectiveness of several beta-lactam antibiotics against many beta-lactamase producing bacteria.

REFERENCES:
patent: 3197466 (1965-07-01), Chow et al.
patent: 3536698 (1970-10-01), Chauvette et al.
Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, edited by J. Elks, Special Publication No. 28, pp. 304-313, Burlington House, (1977), London.
Guddaz et al., Tetrahedron Letters, No. 9, 381, (1962).
Harrison et al., Jour. Chem. Soc., (London), Perkin I, 1772, (1976).
Antibiotki, 13, 155-158, (1968).
Hoogmartens et al., Jour. of Med. Chem., 17, 389, (1974).
Claes et al., European Jour. of Med. Chem. Chimica Therapeutica, 10, 573, (1975).

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