Pellet formulation

Details Pellet formulation Pellet formulation

1988-12-19

1990-02-13

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, 424458, 424462, 424465, 424468, 424482, A61K 922, A61K 952

Patent

active

049005570

ABSTRACT:
The invention relates to pellet formulations which (a) contain at least one active compound, one binder and one weighting agent, (b) are coated with a lacquer which is resistant to gastric juice or have been granulated in the presence of a lacquer which is resistant to gastric juice, it being possible, if appropriate, for the granules to be coated with a lacquer which is resistant to gastric juice, (c) have an apparent density of 1.4 to 2.4 and (d) have a diameter of 0.2 to 1.8 mm.

REFERENCES:
patent: 2801203 (1957-07-01), Leb et al.
patent: 3017329 (1962-01-01), Dulmage
patent: 3056724 (1962-10-01), Marston
patent: 3341417 (1967-09-01), Sinaiko
patent: 3444290 (1969-05-01), Wai
patent: 4193985 (1980-03-01), Bechgaard
patent: 4339463 (1982-07-01), Takagisai
patent: 4572833 (1986-02-01), Pedersen et al.
patent: 4574080 (1986-03-01), Ruswall et al.
patent: 4713248 (1987-12-01), Kjornaes et al.
Bechgaard Distribution of Pellets in the Gastrointestinal Tract, the Influence on Transit Time Exerted by the Density or Diameter of Pellets. J. Pharmac., 1978, 30, 690 to 692.

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