PEGylated soluble GP130-dimers useful as a medicament

Details PEGylated soluble GP130-dimers useful as a medicament PEGylated soluble GP130-dimers useful as a medicament

2008-02-05

2009-12-08

Mertz, Prema (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S320100, C435S325000

Reexamination Certificate

active

07629147

ABSTRACT:
A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.

REFERENCES:
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5783672 (1998-07-01), Mosley et al.
patent: 6838076 (2005-01-01), Patton et al.
patent: 2007/0270334 (2007-11-01), Seegert et al.
patent: 0442724 (1991-08-01), None
patent: 1148065 (2001-10-01), None
patent: 1148065 (2001-10-01), None
Mikayama et al. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060.
Voet et al. Biochemistry John Wiley & Sons, Inc., pp. 126-128 and 228-234.
Eck & Wilson in Goodman & Gilman's the Pharmacological Basis of Therapeutics, Ninth Edition, McGraw-Hill New York, 1996.
Atreya, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. May 2000;6(5):583-8.
Bitter, et al. Expression and Secretion Vectors for Yeast. Methods in Enzymology. 1987;153: 516-544.
Broglie, et al. Light-regulated expression of a pea ribulose-1,5-bisphosphate carboxylase small subunit gene in transformed plant cells. Science. May 25, 1984;224(4651):838-43.
Colbere-Garapin, et al. A new dominant hybrid selective marker for higher eukaryotic cells. J Mol Biol. Jul. 25, 1981;150(1):1-14.
Coruzzi, et al. Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. EMBO J. Aug 1984;3(8):1671-9.
Cunningham, et al. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science. Jun. 2, 1989;244(4908):1081-5.
Cunningham, et al. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. Science. Mar. 10 1989;243(4896):1330-6.
Database UniProt Interleulin-6 receptor beta chain precursor. Feb. 1, 1995, HIBI: “Interleulin signal transducer” XP002322123 retrieved from EBI Database accession No. P40189 abstract.
Engelhard, et al. The insect tracheal system: a conduit for the systemic spread ofAutographa californicaM nuclear polyhedrosis virus. Proc Natl Acad Sci U S A. Apr. 12, 1994; 91(8): 3224-3227.
Fingl, et al. Chapter 1, General Principles, The Pharmocological Basis of Therapeutics, Goodman and Gilman, eds. Macmillan Publishing Co., New York, pp. 1 46 (1975).
Goodson, et al. Site-directed pegylation of recombinant interleukin-2 at its glycosylation site. Biotechnology (N Y). Apr 1990;8(4):343-6.
Grace, et al. Structural and biologic characterization of pegylated recombinant IFN-alpha2b. J Interferon Cytokine Res. Dec. 2001;21(12):1103-15.
Hartman, et al. Two dominant-acting selectable markers for gene transfer studies in mammalian cells. Proc Natl Acad Sci U S A. Nov 1988;85(21):8047-51.
Inoue, et al. A highly enhanced thrombopoietic activity by monomethoxy polyethylene glycol-modified recombinant human interleukin-6 J. Lab Clin. Med. 1994;124(4):529-36.
Katre, N. V Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol. J Immunol. Jan. 1, 1990;144(1):209-13.
Krause, et al. Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J Immunol. Dec. 1, 2002;169(11):6610-6.
Levy, et al. What does Stat3 do? J Clin Invest. May 1, 2002; 109(9): 1143-1148.
Logan, et al. Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc Natl Acad Sci U S A. Jun. 1984;81(12):3655-9.
Lowy, et al. Isolation of transforming DNA: cloning the hamster aprt gene. Cell. Dec. 1980;22(3):817-23.
Mikayama, et al. Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. Proc Natl Acad Sci U S A. Nov. 1, 1993;90(21):10056-10060.
Müllberg, et al. IL-6 receptor independent stimulation of human gp130 by viral IL-6. J Immunol. May 1, 2000;164(9):4672-7.
Murry, L.E., Agrobacterium-Mediated plant transformation in McGraw Hill Yearbook of Science and Technology. McGraw Hill, New York, NY. 1992; 191-196.
Nishimoto, T. A new role of ran GTPase. Biochem Biophys Res Commun Sep. 7, 1999;262(3):571-4.
Nishimoto, et al. Anticytokine therapy in autoimmune diseases. Intern. Med. Feb. 1999; 38(2): 178-82.
Pepinsky, et al. Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity. J Pharmacol Exp Ther. Jun. 2001;297(3):1059-66.
Pettit, et al. Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling. J Biol Chem. Jan. 24, 1997;272(4):2312-8.
Rakemann, et al. The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro. J Biol Chem. Jan. 15, 1999;274(3):1257-66.
Rhodes, et al. Identification of MRF4: a new member of the muscle regulatory factor gene family. Genes Dev. Dec. 1989;3(12B):2050-61.
Rhodes, et al. Transformation of Maize by Electroporation of Embryos. (1995) Methods Mol. Biol. 55: 121 131.
Sambrook, J. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY(1989). (Cover pages and table of contents pages only).
Scharf, et al. Heat stress promoters and transcription factors. Results Probl Cell Differ. 1994;20:125-62.
Suzuki, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med. Feb. 19, 2001;193(4):471-81.
Takamatsu, et al. Expression of bacterial chloramphenicol acetyltransferase gene in tobacco plants mediated by TMV-RNA. EMBO J. Feb. 1987;6(2):307-11.
Tang, et al. Studies on the PEGylation of Protein at a Specific Site: Sulfhydryl-PEGylation of 97Cys-IFN-gamma. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1996;28(3):312-315. (in Chinese with English abstract).
Tsunoda, et al. Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent. Br. J Haematol. 2001;112(1):181-8.
Turkson, et al. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. Dec. 27, 2000;19(56):6613-26.
Voet, et al. Biochemistry. John Wiley & Sons, Inc. 1990; 126-128 and 228-234.
Wigler, et al. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. May 1977;11(1):223-32.
Wigler, et al. Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A. Jun. 1980;77(6):3567-70.
Winter, et al. The expression of heat shock protein and cognate genes during plant development. Results Probl Cell Differ. 1991;17:85-105.
Yoshizaki, et al. Interleukin-6 in autoimmune disorders. Semin Immunol Jun. 1992;4(3):155-66.
Youngster, et al. Structure, biology, and therapeutic implications of pegylated interferon alpha-2b. Curr Pharm Des. 2002;8(24):2139-57.

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