Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-05-15
2000-02-15
Draper, Garnette D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 12, 514909, 530399, 530350, 530351, 530402, 530403, 530404, 530405, 530406, 424 851, 4241931, 4241851, 4241941, 42419511, 4241981, A61K 3822, A61K 3800
Patent
active
060253258
ABSTRACT:
Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and the recombinant expression of these biologically active proteins in purified and homogeneous forms.
REFERENCES:
patent: 4199337 (1980-04-01), Davis et al.
patent: 4609546 (1986-09-01), Hiratoni et al.
patent: 4643969 (1987-02-01), Inouye et al.
patent: 4666836 (1987-05-01), Inouye et al.
patent: 4757013 (1988-07-01), Inouye et al.
patent: 5559208 (1996-09-01), Basinski et al.
patent: 5563243 (1996-10-01), DiMarchi et al.
patent: 5563244 (1996-10-01), DiMarchi et al.
patent: 5563245 (1996-10-01), DiMarchi et al.
patent: 5567678 (1996-10-01), DiMarchi et al.
patent: 5567803 (1996-10-01), Basinski et al.
patent: 5569743 (1996-10-01), DiMarchi et al.
patent: 5569744 (1996-10-01), Basinski et al.
patent: 5574133 (1996-11-01), DiMarchi et al.
patent: 5580954 (1996-12-01), DiMarchi et al.
patent: 5594104 (1997-01-01), Basinski et al.
Gen Bank Accession No. 18812.
Gen Bank Accession No. 18915.
Gen Bank Accession No. 03288.
Gen Bank Accession No. 23332.
Yamasaki, et al., Novel Polyethylene Glycol Derivatives for Modification of Proteins, Agric. Biol. Chem. vol. 52, No. 8, pp. 2125-2127 (1988).
Yamasaki, et al., Some Properties of Ricin D Modified with a Methoxypolyethylene Glycol Derivative, Agric. Biol. Chem, vol. 54, No. 10, pp. 2635-2640 (1990).
Zhang, et al, Positional Cloning of the mouse obese gene and its human homologue, Nature, vol. 372, pp. 425-432 (1994).
DeSutter, et al, Production of enzymatically active rat protein disulfide isomerase in Escherichia coli, Gene, vol. 141, pp. 163-170 (1994).
Friedman, J. M. et al., Genomics 11:1054-62 (1991).
Murakami, et al, Cloning of Rat Obese cDNA and its Expression in Obese Rats, Biochemical and Biophysical Research Communications, vol. 209, No. 3, pp. 944-952, (1995).
Masuzaki, et al., Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue, Diabetes, vol. 44, pp. 855-858 (1995).
Lindpaintner, Finding An Obesity Gene--A Tale of Mice and Man, Clinical Implications of Basic Research, vol. 332, No. 10, pp. 679-680 (1995).
Geffroy, et al., Localization of the Human OB Gene (OBS) to Chromosome 7q32 by Fluorescence in Situ Hybridization, Genomics, vol. 28, pp. 603-604 (1995).
Masuzaki, et al., Adipose Tissue-Specific Expression of the Obese (ob) Gene in Rats and its Marked Augmentation in Genetically Obese-hyperglycemic Wistar Fatty Rats, Proc. Japan Acad, vol. 71, pp. 148-152 (1995).
Green, et al., The Human Obese (OB) Gene:RNA Expression Pattern and Mapping on the Physical, Cytogenetic, and Genetic Maps of Chromosome 7, Genome Research, vol. 5, pp. 5-12 (1995).
Altmann, et al., Expression and Purification of a Synthetic Human Obese Gene Product, Protein Expression and Purification, vol. 6, pp. 722-726 (1995).
Hamilton, et al., Increased obese mRNA expression in omental fat cells from massively obese humans, Nature Medicine, vol. 1, No. 9, pp. 953-956 (1995).
Vydelingum, et al., Overexpression of the Obese Gene in the Genetically Obese JCR:LaA-Corpulent Rat, Biochemical and Biophysical Research Communications, vol. 216, No. 1, pp. 148-153 (1995).
Barinaga, Obese Protein Slims Mice, Science, vol. 269, pp. 475-476 (1995).
Considine, et al., Evidence Against Either a Premature Stop Codon or the Absence of Obese Gene mRNA in Human Obesity, J. Clin. Invest., vol. 95, pp. 2986-2988 (1995).
Funahashi, et al., Enhanced Expression of Rat Obese (ob) Gene in Adipose Tissues of Ventromedial Hypothalamus (VMH)-Lesioned Rats, Biochemical and Biophysical Research Communications, vol. 211, No. 2, pp. 469-475 (1995).
Olefsky, Weighing in on the Lean Genes, J. Clin. Invest., vol. 95, pp. 2427-2428 (1995).
De Vos, Induction of ob Gene Expression by Corticosteroids Is Accompanied by Body Weight Loss and Reduced Food Intake, The Journal of Biological Chemistry, vol. 270, No. 27, pp. 15958-15961 (1995).
Halaas, et al., Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene, Science, vol. 269, pp. 543-546 (1995).
Pelleymounter, et al., Effects of the obese Gene Product on Body Weight Regulation in ob/ob Mice, Science, vol. 269, pp. 540-543 (1995).
Stirling, et al., Identification of Microsatellite Markers Near the Human ob Gene and Linkage Studies in NIDDM-Affected Sib Pairs, Diabetes, vol. 44, pp. 999-1001 (1995).
Frederich, et al., Expression of ob mRNA and its Encoded Protein in Rodents, J. Clin. Invest., vol. 96, pp. 1658-1663 (1995).
MacDougald, et al., Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 andipocytes, Proc. Natl. Acad. Sci, vol. 92, pp. 9034-9037 (1995).
Ogawa, et al., Molecular Cloning of Rat Obese cDNA and Augmented Gene Expression in Genetically Obese Zucker Fatty (fa/fa) Rats, J. Clin. Invest, vol. 96, pp. 1647-1652 (1995).
Rentsch, et al., Recombinant OB-Gene Produce Reduces Food Intake in Fasted Mice, Biochemical and Biophysical Research Communications, vol. 214, No. 1, pp. 131-136 (1995).
Trayhurn, et al. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice, FEBS Letters, vol. 368, pp. 488-490 (1995).
Madej, et al., Threading analysis suggest that the obese gene product may be a helical cytokine, FEBS Letters, vol. 373, pp. 13-18 (1995).
Maffei, et al., Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects, Nature Medicine, vol. 1, No. 11, pp. 1155-1161, (1995).
Cusin, et al., A Relationship Leading to Clues to the Understanding of Obesity, Diabetes, vol. 44, pp. 1467-1470 (1995).
Frederich, et al., Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action, Nature Medicine, vol. 1, No. 12, pp. 1311-1314 (1995).
He, et al., Genomic Organization, Promoter Activity, and Activation by CCAAT/Enhancer-Binding Protein .alpha., The Journal of Biological Chemistry, vol. 270, No. 48, pp. 28887-28891 (1995).
Maffei, et al., Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus, Proc. Natl. Acad. Sci., vol. 92, pp. 6957-6960 (1995).
Moinat, et al., Modulation of obese gene expression in rat brown and white adipose tissues, FEBS Letters, vol. 373, pp. 131-134 (1995).
Murakami, et al., Dexamethasone Regulates Obese Expression in Isolated Rat Adipocytes, vol. 214, No. 3, pp. 1260-1267 (1995).
Isse, Structural Organization and Chromosomal Assignment of the Human Obese Gene, The Journal of Biological Chemistry, vol. 270, No. 46, pp. 27728-27733 (1995).
Weigle, et al., Recombinant ob Protein Reduces Feeding and Body Weight in the ob/ob Mouse, J. Clin. Invest., vol. 96, pp. 2065-2070 (1995).
De Sutter, et al., Production of enzymatically active rat protein disulfide isomerase in Escherichia coli, Gene, vol. 141, pp. 163-170 (1994).
Takahara, et al., The ompA Signal Peptide Directed Secretion of Staphylococcal Nuclease A by Escherichia coli, The Journal of Biological Chemistry, vol. 260, No. 5, pp. 2670-2674 (1985).
Groch, et al., Synthesis of the Bacillus subtilis histone-like DNA-binding protein Hbsu in Escherichia coli and secretion into the periplasm,. Gene, vol. 124, pp. 99-103 (1993).
Barone, et al., The Expression in Escherichia coli of Recombinant Human Platelet Factor 4, a Protein with Immunoregulatory Activity, The Journal of Biological Chemistry, vol. 263, No. 18, pp. 8710-8715 (1988).
Hussain, et al., Expression of ricin B chain in Escherichia coli, FEBS Letters, vol. 244, No. 2, pp. 383-387 (1989).
Libby, et al., Expression and Purification of Native Human Granulocyte-Macrophage Colony-Stimulating Factor from an Escherichia coli Secretion Vector, DNA, vol. 6, No. 3, pp. 221-229 (1987).
Monteilhet, et al., Cytoplasmic and periplasmic production of human apolipoprotein E in Escherichia coli using natural and bacterial signal peptides, Gene, vol. 125, pp. 223-228 (1993).
Parker, et al., Overexpression of native human .beta..sub.2 -microglobulin in Esch
Campfield Arthur
Devos Rene
Guisez Yves
Draper Garnette D.
Epstein William H.
Hoffman-La Roche Inc.
Johnston George W.
Kreisler Lewis J.
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