Pegylated mutated clostridium botulinum toxin

Details Pegylated mutated clostridium botulinum toxin Pegylated mutated clostridium botulinum toxin

2011-08-23

2011-08-23

Navarro, Albert (Department: 1645)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C424S184100

Reexamination Certificate

active

08003601

ABSTRACT:
The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it comprises (i) an extension of the chain on its N-terminus which has the structure —(C)n-(tag)m-(X)l— in the direction from the N- to the C-terminal end, whereinC represents a cysteine residue,tag represents any tag andX represents the residue of any naturally occurring amino acid,n represents an integer from 1 to 50,m represents 0 or 1, andl represents 0 or an integer from 1 to 50,and in that (ii) at least one of the cysteine residues in the extension of the chain is coupled to at least one chain of PEG.

REFERENCES:
patent: 2002/0197278 (2002-12-01), Allison
patent: 2003/0027752 (2003-02-01), Steward et al.
patent: WO 00/74703 (2000-12-01), None
patent: WO 03/000193 (2003-01-01), None
patent: WO 2006/026780 (2006-03-01), None
Lacy et al., “Crystal structure of botulinum neurotoxin type A and implications for toxicity,”Nat. Struct. Biol.5:898-902, 1998.
Schantz et al., “Properties and use of botulinum toxin and other microbial neurotoxins in medicine,”Microbiological Reviews, 56(1): 80-99, 1992.
Swaninathan et al., “Structural analysis of the catalytic and binding sites ofClostridium botulinumneurotoxin B,”Nat. Struct. Biol., 7:693-699, 2000.
Bavari et al., “Identifying the principal protective antigenic determinants of type A botulinum neurotoxin,”Vaccine, 16(19):1850-1856, 1998.

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