Pegylated interleukin-10

Details Pegylated interleukin-10 Pegylated interleukin-10

2006-05-30

2006-05-30

Webman, Edward J. (Department: 1616)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C435S069520, C530S351000, C530S345000, C530S402000, C530S406000, C424S078300, C424S078380, C514S002600, C514S012200, C525S054100

Reexamination Certificate

active

07052686

ABSTRACT:
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.

REFERENCES:
patent: 5252714 (1993-10-01), Harris et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5824784 (1998-10-01), Kinstler
patent: 5908621 (1999-06-01), Glue et al.
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5951974 (1999-09-01), Gilbert et al.
patent: 5985265 (1999-11-01), Kinstler et al.
patent: 6217857 (2001-04-01), Mosmann et al.
patent: 2003/0186386 (2003-10-01), Hansen et al.
patent: 0 251 304 (1988-01-01), None
patent: WO 9506058 (1995-03-01), None
patent: WO 9611953 (1996-04-01), None
patent: WO 9932134 (1999-07-01), None
patent: WO 0158950 (2001-08-01), None
U.S. Appl. No. 60/184,024.
U.S. Appl. No. 60/230,093.
Modification of CD4 Immunoadhesin with Monomethoxypoly(ethylene glycol) Aldehyde via Reductive Alkylation, Chamow et al., Bioconjugate Chem. 5, 133-140 (1994).
The conjugation of proteins with polyethylene glycol and other polymers Altering properties of proteins to enhance their therapeutic potential, N.V. Katre, Advanced Drug Delivery Reviews 10:91-114 (1993).
Characterization and Stability of N-terminally PEGylated rhG-CSF, Kinstler et al., Pharm. Res. 13:996-1002 (1996).
Administration of Interleukin-10 at the Time of Priming Protects Corynebacterium parvum-Primed Mice against LPS- and TNF-α-Induced Lethality, Smith et al., Cellular Immunology 173:207-214 (1996).
International Search Report, Patent Cooperation Treaty, International Application No. PCT/US 01/42431, Aug. 9, 2002.

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