Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1998-09-01
2000-12-26
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424488, A61K 4734, A61K 4732
Patent
active
061655090
ABSTRACT:
PEGylated drugs complexed with bioadhesive polymers, wherein the PEGylated drugs comprise a polyethylene glycol covalently bonded to the drugs are disclosed. The PEGylated drug/bioadhesive polyner complex and compositions thereof may be topically administered to body fluids or mucosal tissues. Methods of administering the PEGylated drug/bioadhesive polymer complex and compositions thereof to an animal are also disclosed.
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Sawbney et al., "Biocrodible Hydrogeis Based on Photopolymerized Poly(ethylene glycol-on-poly(.alpha.-hydroxy acid) Diacrylate-Macromes," Macromolecules 26:581-587, 1993.
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Zhao and Harris, "Novel Degradable Poly(ethylene glycol) Esters for Drug Delivery," ACS Symposium Series 630:458-472, 1997.
Hayashi Yoshiki
Hoffman Allan S.
Kulkosky Peter F.
University of Washington
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