PEG-modified antibody with reduced affinity for cell surface Fc

Details PEG-modified antibody with reduced affinity for cell surface Fc PEG-modified antibody with reduced affinity for cell surface Fc

1984-12-31

1988-03-22

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

424 11, 424 9, 436548, 436804, 436813, 530387, G01N 3353, G01N 33532, G01N 33574, G01N 33577

Patent

active

047328630

ABSTRACT:
PEG-modified protein molecules characterized by reduced immunogenicity are prepared by covalent modification of the protein with PEG employing an active ester intermediate. Antibodies so modified exhibit decreased binding capacity for Fc cell surface receptors, are non-toxic and retain full antigen binding activity, and are consequently useful in a variety of immunologically-based diagnostic and therapeutic procedures.

REFERENCES:
patent: 4384993 (1983-05-01), Sato et al.
patent: 4407965 (1983-10-01), Yanaihara
patent: 4427653 (1984-01-01), Springer
patent: 4495285 (1985-01-01), Shimizu
Boccu, E. et al., Z. Naturforsch., Section C, Biosci, vol. 38c, No. 1/2, 94-99 (1983).
Chemical Abstracts, 98:15249k (1983).
Ling, T. G. I. et al., J. Immunol. Meth., 59, 327-337 (1983).
Mellman et al, "Purification of a Functional Mouse Fc Receptor Through the Use of a Monoclonal Antibody", J. Exp. Med., vol. 152, Oct. 1980, pp. 1048-1049.

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