Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-08-26
1995-01-17
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 854, 424 857, 530409, 530410, 546300, 546301, 558276, C07D21389, C07K 308, C07K 1526
Patent
active
053826574
ABSTRACT:
Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.
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Karasiewicz Robert
Nalin Carlo
Rosen Perry
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Roseman Catherine R.
Russel Jeffrey E.
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