Pectinophora gossypiella (pink bollworm) Bacillus...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C530S350000, C530S300000, C536S023500, C536S023710

Reexamination Certificate

active

07094554

ABSTRACT:
A cDNA encoding a 200 kD receptor, BT-R2, from the pink boll worm,Pectinophora gossypiella,that binds specifically to aBacillus thuringiensistoxin has been cloned, sequenced and characterized. The minimum toxin binding fragment has been identified. The BT-R2cDNA permits the analysis of receptors in pink boll worm and other insects that affect crop growth and development, as well as, design assays for the cytotoxicity and binding affinity of potential pesticides. The clone and other methods described herein, permit the manipulation of natural and/or introduced homologous receptors and, thus, to specifically destroy organisms, tissues and/or cells of the target host.

REFERENCES:
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Nagamatsu et al., Biosci. Biotechnol. Biochem. (1998) 62:727-734.
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