PDZK1 protein containing PDZ interaction domains

Details PDZK1 protein containing PDZ interaction domains PDZK1 protein containing PDZ interaction domains

1997-12-23

2000-03-28

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 6, 435 723, C07K 100, C12Q 168, G01N 33574

Patent

active

060433426

ABSTRACT:
The present invention provides a unique DNA segment and a previously unknown PDZK1 protein as a marker system indicative of cells and tissues in an abnormal cellular state and which are undergoing a progressive loss of cell regulation and control. The isolated DNA sequence encodes the PDZK1 protein; and the expressed PDZK1 protein, particularly when present in large or excessive quantitative amounts, is a reliable and reproducible biochemical marker that an ongoing neoplastic development is occurring within cell and tissues of epithelial cell origin.

REFERENCES:
Yang et al. Experimental Cell Research. vol. 241, No. 1. pp. 242-252, May 1998.
Kocher et al. Laboratory Investigation. vol. 78, No. 1, pp. 117-125, 1998.
White et al. Ann. Hum. Genet. vol. 62, pp. 287-290, 1998.

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