PDGF receptor kinase inhibitory compounds their preparation and

Details PDGF receptor kinase inhibitory compounds their preparation and PDGF receptor kinase inhibitory compounds their preparation and

1997-12-01

1999-08-03

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514250, 544344, 544345, 544353, A01N 4358, C07D24136, C07D47100

Patent

active

059325801

ABSTRACT:
PDGF receptor kinase inhibitory compounds of the quinoxaline family, methods for their synthesis and containment is slow release pharmaceutical preparations, and their use for treatment of proliferative malignant and non-malignant diseases or disorders by local or systemic application. A compound according to the invention includes a tyrphostin of the general formula: ##STR1## wherein R1 and R2 are each independently selected from the group consisting of alkyl, alkoxy, halogen, nitro and amine and Ar is selected from the group consisting of phenyl, ferrocene, thiophene, furane, pyrrole, indole, thiazole, imidazole and pyridine.

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