PDGF antagonists II

Details PDGF antagonists II PDGF antagonists II

1996-05-29

1998-03-24

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 514415, 514418, A61K 31445, A61K 3140, A61K 31405

Patent

active

057313261

ABSTRACT:
Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal a non-peptide PDGF antagonist such as 4-(2-(N-(2-carboxamidoindole)aminoethyl)-benzenesulfonamides or sulfonylureas. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.

REFERENCES:
patent: 5280016 (1994-01-01), Conrad et al.
Peuler et al., American Journal of Hypertension 9: 188-192, 1996.
Ambrogi et al., Arzneim.-Forsch (Drug Res.) 21: 204-208, 1971.
Kimura et al., Japan J. Pharmacol. 59: 51-56, 1992.
Cavari et al., Cell Biol. Intl. 17(8): 781-786, 1993.
Castellot et al., J. Cell. Biol. 109(6): 3147-3155, 1989.
Reilly et al., J. Cell. Phys. 136: 23-32, 1988.
Guyton et al., Circulation Research 46(5): 625-634, 1980.
Popma et al., Circulation 84(3); 1426-1436, 1991.
Ferrell et al., Circulation 85(4): 1630-1631, 1992.
Lindner et al., J. Clin. Invest. 90: 2044-2049, 1992.
Jawien et al., J. Clin. Invest. 89: 507-511, 1992.
Lindner et al., J. Clin. Invest. 85: 2004-2008, 1990.
Currier et al., JACC 17: 118B-125B, 1991.
Schmid et al., Seminars in Thrombosis and Hemostasis 19, Suppl. 1: 155-159, 1993.
Edelman et al., Proc. Natl. Acad. Sci. USA 87: 3773-3777, 1990.
Rubin et al., Lancet Jun. 18, 1988: 1353-1356, 1988.
Buchwald et al., Circulation 86(2): 531-537, 1992.

Affiliated with

Also associated with

Rating

PDGF antagonists II does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PDGF antagonists II, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PDGF antagonists II will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2289216