PDGF analogs and methods of use

Details PDGF analogs and methods of use PDGF analogs and methods of use

1988-08-08

1992-07-07

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530399, 530350, 530300, 514970, A61K 3737

Patent

active

051283212

ABSTRACT:
Proteins having substantially the same biological activity as PDGF are provided. In one aspect, a protein homodimer having two polypeptide chains is disclosed, each of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- and B-chains of PDGF, the protein being chemotactic or mitogenic for fibroblasts. Therapeutic compositions comprising such proteins in combination with a physiologically acceptable carrier or diluent are also provided. Such therapeutic compositions may be used within methods for enhancing the wound-healing process in warm-blooded animals.

REFERENCES:
patent: 4766073 (1988-08-01), Murray
patent: 4849407 (1989-07-01), Murray
patent: 4861757 (1989-08-01), Antoniades et al.
patent: 4874746 (1989-10-01), Antoniades et al.
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Leitzel at al., "Growth Factors and Wound Healing in the Hamster", Dermatol. Surg. Oncol. 11:617-622, 1985.
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