PDEs and uses thereof

Details PDEs and uses thereof PDEs and uses thereof

2006-06-01

2009-10-06

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07598067

ABSTRACT:
The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

REFERENCES:
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4777019 (1988-10-01), Dandekar
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5080548 (1992-01-01), Bratlie et al.
patent: 5110802 (1992-05-01), Cantin et al.
patent: 5194428 (1993-03-01), Agrawal et al.
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5798246 (1998-08-01), Au-Young et al.
patent: 5922595 (1999-07-01), Fisher et al.
patent: 5932423 (1999-08-01), Au-Young et al.
patent: 5932465 (1999-08-01), Loughney
patent: 6080548 (2000-06-01), Au-Young et al.
patent: 6686196 (2004-02-01), Lieber et al.
patent: 7138259 (2006-11-01), Beavo et al.
patent: WO 99/19495 (1999-04-01), None
Fisher et al. [BBRC, 246:570-577, May 29, 1998].
Abdullah et al., “A Neutral Glycoprotease ofPasteurella haemolyticaA1 Specifically Cleaves O-Sialoglycoproteins,”Infect. Immun. 60:56-62 (1992).
Alexandre et al., “Differential Expression of a Family of Putative Adenylate/Guanylate Cyclase Genes inTrypanosoma brucei,”Mol Biochem. Parasitol. 43:279-88 (1990).
Alexandre et al., “Families of Adenylate Cyclase Genes inTrypanosoma brucei,”Mol. Biochem. Parasitol. 77:173-82 (1996).
Altschul et al., “Basic Local Alignment Search Tool,”J. Mol. Biol. 215:403-10 (1990).
Aravind & Ponting, “The GAF Domain: An Evolutionary Link Between Diverse Phototransducing Proteins,”Trends Biochem. Sci. 22:458-9 (1997).
Arnon et al., “Monoclonal Antibodies for Immunotargeting of Drugs in Cancer Therapy,”in Monoclonal Antibodies and Cancer Therapy243-56 (Reisfeld & Sell eds., 1985).
Arthur et al., “A Comparison of Gene Transfer Methods in Human Dendritic Cells,”Cancer Gene Ther. 4:17-25 (1997).
Ashley et al., “Bone Marrow-generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity Against Central Nervous System Tumors,”J. Exper. Med. 186:1177-82 (1997).
Atienza & Colicelli, “Yeast Model System for Study of Mammalian Phosphodiesterases,”Methods14:35-42 (1998).
Baiget et al., “IdentificaciOn de Dos Mutaciones Aléhcas en el Gen de la Subunidad Beta de la Fosfodiesterasa en Una Familia Espanola Afectada de Retinosis Pigmentaria Autósomica Recesiva,”Meditina Clinica111:420-22 (1998).
Bastin et al., “A Novel Epitope Tag System to Study Protein Targeting and Organelle Biogenesis inTrypanosoma brucei,”Mol. Biochem. Parasitol. 77:235-9 (1996).
Beavo & Reifsnyder, “Primary Sequence of Cyclic Nucleotide Phosphodiesterase Isozymes and the Design of Selective Inhibitors,”Trends Pharmacol. Sci. 11:150-5 (1990).
Benashski et al., “Dimerization of the Highly Conserved Light Chain Shared by Dynein and Myosin V,”J. Biol. Chem. 272:20929-35 (1997).
Berent et al., “Comparison of Oligonucleotide and Long DNA Fragments as Probes in DNA and RNA Dot, Southern, Northern, Colony and Plaque Hybridizations,”Biotechniques3:208-18 (1985).
Berkner, “Development of Adenovirus Vectors for the Expression of Heterologous Genes,”Biotechniques6:616-29 (1988).
Bitter et at, “Expression and Secretion Vectors for Yeast,”Methods Enzymol. 153:516-44 (1987).
Bloom et al., “Identification and Tissue-specific Expression of PDE7 Phosphodiesterase Splice Variants,”Proc, Nat'l Acad. Sci. USA93:14188-92 (1996).
Bodley et al., “Drug Cytotoxicity Assay for African Trypanosimes andLeishrnania Species,”J. Infec. Dis. 172:1157-9 (1995).
Borden, “Ring Fingers and B-Boxes: Zinc-Binding Protein-Protein Interaction Domains,”Biochem. Cell Biol. 76:351-8 (1998).
Borrebaeck et al., “Human Monoclonal Antibodies Produced by Primary in Vitro Immunization of Peripheral Blood Lymphocytes,”Proc. Nat'l Acad. Sci. USA85:3995-9 (1988).
Brisson et al., “Expression of a Bacterial Gene in Plants by Using a Viral Vector,”Nature310:511-4 (1984).
Brogue et al., “Light-Regulated Expression of a Pea Ribulose-1,5-Bisphosphate Carboxylase Small Subunit Gene in Transformed Plant Cells,”Science224:838 43 (1984).
Brun et al., “Cultivation of Vertebrate Infective Forms Derived from Metacyclic Forms of PleomorphicTypanosoma bruceiStocks,”Acta Tropica36:387-90 (1979).
Capecchi, “Altering the Genome by Homologous Recombination,”Science244:1288-92 (1989).
Charbonneau et al., “Identification of a Conserved Domain Among Cyclic Nucleotide Phosphodiesterases from Diverse Species,”Proc. Nat'l Acad. Sci. USA83:9308-12 (1986).
Clayton et al., “Short Communication: Genetic Nomenclature forTrypanosoma and Leishmama,” Mol. Biochem. Parasitol. 97:221-4 (1998).
Cohen et al., “Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation ofEscherichia coliby R-Factor DNA,”Proc. Nat'l Acad. Sci. 69:2110-4 (1972).
Colbére-Garapin et al., “A New Dominant Hybrid Selective Marker for Higher Eukaryotic Cells,”J. Mol. Biol. 150:1-14 (1981).
Corruzi et al., “Tissue-specific and Light-regulated Expression of a Pea Nuclear Gene Encoding the Small Subunit of Ribulose-1,5-bisphosphate Carboxylase,”EMBO J. 3:1671-9 (1984).
Crépieux et al., “IχBα Physically Interacts with a Cytoskeleton-associated Protein Through Its Signal Response Domain,”Mol. Cell Biol. 17:7375-85 (1997).
Dekomien & Epplen, “Short Communication: Exclusion of the PDE6A Gene for Generalized Progressive Retinal Atrophy in 11 Breeds of Dog,”Anim, Genet. 31:135-9 (2000).
Dickinson et al., “Activation of cGMP-stimulated Phosphodiesterase by Nitroprusside Limits cAMP Accumulation in Human Platelets: Effects on Platelet Aggregation,”Biochem. J. 323:371-7 (1997).
Dousa, “Cyclic-3 ',5'-nucleotide Phosphodiesterase Isozymes in Cell Biology and Pathophysiology of the Kidney,”Kidney Int'55:29-62 (1999).
Dugas & Penney, Bioorganic Chemistry 54-92.
Dunlap & Callahan, “Characterization of a Periplasmic 3':5'-Cyclic Nucleotide Phosphodiesterase Gene,cpdP, from the Marine Symbiotic BacteriumVibrio fischeri,”J. Bacteriol. 175:4615-24 (1993).
Ekholm et al., “Differential Expression of Cyclic Nucleotide Phosphodiesterase 3 and 4 Activities in Human T Cell Clones Specific for Myelin Basic Protein,”J. Immunol. 159:1520-9 (1997).
Elghetany, “Surface Marker Abnormalities in Myelodysplastic Syndromes,”Haematologica83:1104-15 (1998).
Engelhard et al., “The Insect Tracheal System: A Conduit for the Systemic Spread ofAutographa CalifornicaM Nuclear Polyhedrosis Virus,” Proc. Nat'Acad. Sci. USA91:3224-7 (1994).
Erdogan & Houslay, “Challenge of Human Jurkat T-Cells with the Adenylate Cyclase Activator Forskolin Elicits Major Changes in cAMP Phosphodiesterase (PDE) Expression by Up-regulating PDE3 and Inducing PDE4D1 and PDE4D2 Splice Variants as well as Down-regulating a Novel PDE4A Splice Variant,”Biochem. J. 321:165-75 (1997).
Fawcett et al., “Molecular Cloning and Characterization of a Distinct Human Phosphodiesterase Gene Family: PDE11A,”Proc. Nat'l Acad. Sci. USA97:3702-7 (2000).
Fell et al., “Homologous Recombination in Hybridoma Cells: Heavy Chain Chimeric Antibody Produced by Gene Targeti

Affiliated with

Also associated with

Rating

PDEs and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PDEs and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PDEs and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4137164