PDE11A mutations in adrenal disease

Details PDE11A mutations in adrenal disease PDE11A mutations in adrenal disease

2007-01-19

2010-12-07

Ton, Thaian N (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S325000, C424S093210

Reexamination Certificate

active

07847078

ABSTRACT:
The invention provides previously uncharacterized variants of PDE11A that are correlated with a newly discovered form of Cushing Syndrome that presents at a young age. The invention also provides methods useful to research, screen for, treat, or prevent diagnose the disease using the PDE11A variants, as well as other methods relating thereto.

REFERENCES:
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: 2003/0190672 (2003-10-01), Omori et al.
patent: WO 2004/029617 (2004-04-01), None
patent: WO 2006/092175 (2006-09-01), None
Strategene Catalog, p. 39, 1998.
Barzon et al.,Eur. J. Endocrinol., 149, 273-285 (2003).
D'Andrea et al.,J. Histochem. Cytochem., 53 (7), 895-903 (2005).
EBI Accession No. AC073834 (2000).
Fawcett et al.,PNAS, 97 (7), 3702-3707 (2000).
Gbekor et al.,J. Urol., 167 (4), No. 967, 246 (2002).
GenBank Accession No. AB048423.
GenBank Accession No. BAB52712.
GenBank Accession No. BAB62713.
GenBank Accession No. BAB62714.
GenBank Accession No. NM—016953.
GenBank Accession No. NP—058649.
Gunther et al.,J. Clin. Endocrinol. Metab., 89 (7), 3173-3182 (2004).
Hetman et al.,PNAS, 97 (23),12891-12895 (2000).
Horvath et al.,Cancer Res., 66 (24), 11571-11575 (2006).
Horvath et al.,Nat. Genet., 38 (7), 794-800 (2006).
International Search Report PCT/US2007/060746.
Loughney et al.,Int. J. Impot. Res., 17, 320-325 (2005).
Saenz De Tejada et al.,Int. J. Impot. Res., 14(Suppl 4), S20-S32 (2002).
Stratakis,Horm. Metab. Res., 39 (6), 467-473 (2007).
Yuasa et al.,Eur. J. Biochem., 268, 168-178 (2001).
Yuasa et al.,Eur. J. Biochem., 268, 4440-4448 (2001).
Yuasa et al.,J. Biol. Chem., 275 (40), 31469-31479 (2000).

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