PD-1-lacking mouse and use thereof

Details PD-1-lacking mouse and use thereof PD-1-lacking mouse and use thereof

2001-11-14

2008-08-19

Chen, Shin-Lin (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C800S014000

Reexamination Certificate

active

07414171

ABSTRACT:
The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to the antibody and is produced in heart, and a diagnostic method for dilated cardiomyopathy using the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, and specifically dilated cardiomyopathy, they are useful for screening for medicines against these diseases.

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Korean Office Action.

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