PD-1, a receptor for B7-4, and uses therefor

Details PD-1, a receptor for B7-4, and uses therefor PD-1, a receptor for B7-4, and uses therefor

2006-09-05

2006-09-05

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S143100, C530S387100, C530S388220, C530S388230

Reexamination Certificate

active

07101550

ABSTRACT:
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.

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