PCV-2 vaccine

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S345000

Reexamination Certificate

active

08008001

ABSTRACT:
The present invention relates to a vaccine and a method for protecting piglets against PCV-2 infection by administering a vaccine comprising at least 20 micrograms/dose of ORF-2 protein of porcine circovirus type 2, even when they have a relatively high titer of maternally derived antibodies against PCV-2. A vaccine according to the invention may contain a recombinant ORF-2 protein, wherein said recombinant protein is preferably produced by way of expression from a baculovirus expression vector in insect cells, said baculovirus expression vector containing the PCV-2 ORF-2 gene sequence under control of a suitable promoter.

REFERENCES:
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patent: 6703023 (2004-03-01), Jestin et al.
patent: 7223407 (2007-05-01), Jestin et al.
patent: 03049703 (2003-06-01), None
Opriessnig et al, Clinical and Vaccine Immunology, Mar. 2008[Available online on Dec. 19, 2007]; vol. 15, No. 3, pp. 397-401.
Tischer et al, Archives of Virology, 1995, vol. 140; pp. 737-743.
Blanchard, P. et al., Vaccine, 21:4565-4575 (2003).
Kamstrup, S. et al., Vaccine, 22:1358-1361 (2004).
Siegrist, C-A., Vaccine, 21:3406-3412 (2003).
Chae, C.,The Veterinary Journal, 169:326-336 (2005).

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