Patterned gradient wound dressing and methods of using same...

Details Patterned gradient wound dressing and methods of using same... Patterned gradient wound dressing and methods of using same...

2011-05-03

2011-05-03

Allen, Marianne P (Department: 1647)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C424S447000, C602S050000

Reexamination Certificate

active

07935364

ABSTRACT:
The present invention provides a wound dressing that includes a patterned gradient of immobilized growth factor molecules that promote directed migration of cells during dermal wound healing. Growth factor is immobilized on a support substrate to present a gradient pattern of increasing growth factor concentration to migrating cells. Methods of promoting wound healing using the patterned gradient wound dressing and fabrication methods of same are also provided.

REFERENCES:
patent: 6596296 (2003-07-01), Nelson et al.
patent: 2003/0175410 (2003-09-01), Campbell et al.
patent: 2005/0026836 (2005-02-01), Dack et al.
patent: WO 2007/085626 (2007-08-01), None
Chung et al., Biomaterials, 23(24):4803-4809, 2002.
Mi et al., Biomaterials, 22:165-73, 2001.
Karakecili et al., Acta Biomateriala, 4(4):989-96, 2008 (available on-line Feb. 19, 2008).
Chen et al. Biomaterials, 22(18):2453-7, 2001.
Ito, Biomaterials, 20:23333-42, 1999.
Kapur, T.A., et al., “Immobilized concentration gradients of nerve growth factor guide neurite outgrowth”, J. Biomed. Mater. Res. A., 2004, 68A: 235-243.
Gobin, A.S., et al., “Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels”, Biotechnol. Prog., 2003, 19: 1787-1785.
DeLong, S.A., et al., “Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration”, Biomaterials, 2005, 26:3227-3234.
Burdick, J.A. et al., “Fabrication of gradient hydrogels using a microfluidics/photopolymerization process”, Langmuir, 2004, 20: 5153-5156.
Zaari, N., et al., “Photopolymerization in microfluidic gradient generators: microscale control of substrate compliance to manipulate cell response”, Adv. Mater., 2004, 16: 2133-2137.
Masters, K.S., et al. “Immobilized gradients of epidermal growth factor promotes accelerated and directed keratinocyte migration”, Wound Repair Regen., 2007, 15 (6): 847-855.
Stefonek-Puccinelli, T.J., et al. “Co-immobilization of gradient-patterned growth factors for directed cell migration”, Ann. Biomed. Eng., 2008, 36 (12): 2121-2133.

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