Pathogenic Escherichia coli associated protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C530S387100, C424S241100

Reexamination Certificate

active

11411382

ABSTRACT:
The present invention provides a polypeptide, called EspA, which is secreted by pathogenicE. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC)E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producingE. coli.

REFERENCES:
patent: 6090623 (2000-07-01), Harpold et al.
patent: 2 078 716 (1994-03-01), None
patent: WO 97 40063 (1997-10-01), None
Abe et al., “Characterization of two virulence proteins secreted by rabbit enteropathogenicEscherichia coli, EspA and EspB, whose maximal expression is sensitive to host body temperature,”Infection and Immunity, Sep. 1997, 65(9), 3547-3555.
Agin et al.,FEMS Microbiol. Lett., Nov. 1996, 144(2-3), 249-258.
Choi et al.,Mamm. Genome, 1995, 6(9), 653-657.
Donnenberg, M.S., Submitted Oct. 9, 1995, GenBank Accession No. Z54352.
Ebel et al.,Infect. Immun., 1996, 64(11), 4472-4479.
Finlay et al., “EnterpathogenicE. coliexploitation of host epithelial cells,”Annals of New York Academy of Sciences, 1996, 797, 26-31.
Jarvis et al., “EnteropathogenicEscherichia colicontainsa putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation,”PNAS USA, Aug. 15, 1998, 92(17), 7996-8000.
Jarvis et al., “Secretion of extracellular proteins by enterohemorrhagicEscherichi colivia a putative Type III secretion system,”Infection and Immunity, Nov. 11, 1996, 64(11), 4826-4829.
Kenny et al., “EspA, a protein secreted by enterpathogenicEscherichia coliis required to induce signals in epithelial cells,”Molecular Microbiology, 1996, 20(2), 313-323.
Kenny et al., “Protein secretion by enteropathogenicEscherichia coliis essential for tranducing signals to epithelial cells,”PNAS USA, Aug. 15, 1995, 92(17), 7991-7995.
Li et al., Human response toEscherichia coliO157:H7 infection: Antibodies to secreted virulence factors.
Murphy et al., “Somatic antigens ofHaemophilus influenzaeas vaccine components,”Pediatr. Infec. Dis. J., 1989, 8, S66-S68.
Mikayama et al.,Proc. Natl. Acad. Sci. USA, Nov. 1993, 90, 10056-10060.
Rudinger et al.,Peptide Hormones Biol. Council, Jun. 1976, 5-7.
Yamanka et al., “Antibody response to outer membrane protein of nontypeableHaemophilus influenzaein otitis-prone children,”J. Pediatrics, 1993, 122(2), 212-218.
Abe, A. et al., “Escherichia colisecreted protein Esp A (espA) gene,” GenBank Accession No. U80908, 1997.
Abe, A. et al., “Escherichia colisecreted protein EspB (espB) gene,” GenBank Accession No. U80796, 1997.
Donnenberg, M.S. et al., “Escherichia coliespB gene,” GenBank Accession No. Z21555, 2000.
Ebel, F. et al., “E. coliespB gene,” GenBank Accession No. X96953, 1997.
Kohler et al., “Continuous cultures of fused cells secreting antibody of predefined specificity,”Nature, 1975, 256(495).
Kresse, A.U. et al., “E. coliespB gene,” GenBank Accession No. X99670, 1997.
Lai, L.C. et al., “E. coliespD gene,” GenBank Accession No. Y09228, 1997.

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